Mitragynine

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 PubMed Articles

1. Pharmacology of Kratom: An Emerging Botanical Agent with Stimulant, Analgesic, and Opioid-like Effects

• Link: Pharmacology of Kratom
• Summary: This article provides an overview of the pharmacological properties of kratom, including its primary alkaloid, mitragynine. It discusses the stimulant and opioid-like effects, potential therapeutic uses, and safety concerns.

2. 7-Hydroxymitragynine: An active Metabolite of Mitragynine and Mediator of Analgesic Effects

• Link: Mitragynine and 7-Hydroxymitragynine
• Summary: This review focuses on the two main active compounds in kratom, mitragynine and 7-hydroxymitragynine. It covers their pharmacodynamics, pharmacokinetics, and potential medicinal applications.

3. Mitragynine, Clinical, Toxicological Aspects and Analysis in Biological and non-Biological Samples

• Link: Clinical Toxicology
• Summary: This study investigates the binding properties of mitragynine to various receptors, including alpha-1 adrenergic and mu-opioid receptors, elucidating its mechanism of action.

4. Involvement of Mu-Opioid Receptor in the Antinociceptive Effect of Mitragynine

• Link: Mu-Opioid Receptor
• Summary: The research highlights the role of the mu-opioid receptor in the pain-relieving (antinociceptive) effects of mitragynine.

1. National Center for Complementary and Integrative Health (NCCIH) - Kratom

• Link: NCCIH Kratom Overview
• Summary: This page provides a comprehensive overview of kratom, including information on its active compounds, such as mitragynine, potential benefits, and risks.

2. National Institute on Drug Abuse (NIDA) - Kratom

• Link: NIDA Kratom Information
• Summary: This resource offers facts about kratom, including its pharmacological effects, potential health impacts, and concerns related to its use.

3. PubChem - Mitragynine

• Link: PubChem Mitragynine
• Summary: PubChem provides detailed chemical information about mitragynine, including its structure, properties, biological activities, safety, and toxicity data.

These resources should provide a solid foundation for understanding the properties, effects, and current research on mitragynine.

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