7-hydroxymitragynine

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7-Hydroxymitragynine is a naturally occurring alkaloid found in the leaves of the kratom tree (Mitragyna speciosa). It is considered one of the primary active compounds in kratom, alongside mitragynine. 7-hydroxymitragynine is formed endogenously from mitragynine during CYP enzyme metabolism.

• Structure: 7-Hydroxymitragynine is a derivative of mitragynine and shares a similar indole-based structure.
• Molecular Formula: C23H30N2O5

• Mechanism of Action: 7-Hydroxymitragynine acts primarily on the mu-opioid receptors, similar to mitragynine but with significantly higher potency. It is estimated to be more potent than mitragynine and even morphine.
• Effects: This compound is known for its potent analgesic (pain-relieving) effects and is considered one of the main contributors to kratom's opioid-like effects. It also exhibits sedative properties.

• Therapeutic Potential: Like mitragynine, 7-hydroxymitragynine is being studied for its potential in pain management and as an alternative to traditional opioid medications. Its high potency makes it a significant focus in kratom-related research.

• Safety: 7-Hydroxymitragynine, due to its high potency, carries a risk of dependence, addiction, and other opioid-like side effects. Long-term use and high doses can lead to adverse effects similar to those of opioid drugs.
• Legal Status: The legal status of 7-hydroxymitragynine, like that of kratom, varies by region. It is important to check local regulations regarding its use.

7-Hydroxymitragynine is a potent alkaloid in kratom that plays a significant role in its analgesic and sedative effects. It holds potential for therapeutic use but also poses risks similar to those of opioids.

1. Mitragynine and 7-Hydroxymitragynine: The Two Main Active Compounds of the Emerging Natural Product Kratom

• Link: Mitragynine and 7-Hydroxymitragynine
• Summary: This review focuses on the pharmacodynamics, pharmacokinetics, and potential medicinal applications of mitragynine and 7-hydroxymitragynine, the two main active compounds in kratom.

2. Pharmacokinetics of Mitragynine and 7-Hydroxymitragynine in Rats

• Link: Pharmacokinetics in Rats
• Summary: This study investigates the pharmacokinetics of mitragynine and 7-hydroxymitragynine in rats, providing insights into their absorption, distribution, metabolism, and excretion.

3. 7-Hydroxymitragynine, an Active Alkaloid of the Plant Kratom (Mitragyna speciosa): State of the Art Review

• Link: State of the Art Review
• Summary: This review provides a comprehensive overview of 7-hydroxymitragynine, including its chemistry, pharmacology, and potential therapeutic uses
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4. Involvement of 7-Hydroxymitragynine in the Antinociceptive Effects of Mitragynine in Mice

• Link: Antinociceptive Effects in Mice
• Summary: The study examines the role of 7-hydroxymitragynine in the pain-relieving effects of mitragynine, highlighting its significance in kratom's overall analgesic properties.

1. National Center for Complementary and Integrative Health (NCCIH) - Kratom

• Link: NCCIH Kratom Overview
• Summary: This page provides an overview of kratom, including information on its active compounds such as 7-hydroxymitragynine, potential benefits, and associated risks.

2. National Institute on Drug Abuse (NIDA) - Kratom

• Link: NIDA Kratom Information
• Summary: This resource offers facts about kratom, including the pharmacological effects of its compounds like 7-hydroxymitragynine, and concerns related to its use.

3. PubChem - 7-Hydroxymitragynine

• Link: PubChem 7-Hydroxymitragynine
• Summary: PubChem provides detailed chemical information about 7-hydroxymitragynine, including its structure, properties, biological activities, safety, and toxicity data.

These resources should give you a comprehensive understanding of 7-hydroxymitragynine, its properties, effects, and current research.