7-hydroxymitragynine
Information on 7-hydroxymitragynine
What is 7-Hydroxymitragynine?
7-Hydroxymitragynine is a naturally occurring alkaloid found in the leaves of the kratom tree (Mitragyna speciosa). It is considered one of the primary active compounds in kratom, alongside mitragynine. 7-hydroxymitragynine is formed endogenously from mitragynine during CYP enzyme metabolism.
Chemical Properties
- Structure: 7-Hydroxymitragynine is a derivative of mitragynine and shares a similar indole-based structure.
- Molecular Formula: C23H30N2O5
Pharmacology
- Mechanism of Action: 7-Hydroxymitragynine acts primarily on the mu-opioid receptors, similar to mitragynine but with significantly higher potency. It is estimated to be more potent than mitragynine and even morphine.
- Effects: This compound is known for its potent analgesic (pain-relieving) effects and is considered one of the main contributors to kratom's opioid-like effects. It also exhibits sedative properties.
Uses
- Therapeutic Potential: Like mitragynine, 7-hydroxymitragynine is being studied for its potential in pain management and as an alternative to traditional opioid medications. Its high potency makes it a significant focus in kratom-related research.
Safety and Legal Status
- Safety: 7-Hydroxymitragynine, due to its high potency, carries a risk of dependence, addiction, and other opioid-like side effects. Long-term use and high doses can lead to adverse effects similar to those of opioid drugs.
- Legal Status: The legal status of 7-hydroxymitragynine, like that of kratom, varies by region. It is important to check local regulations regarding its use.
Conclusion
7-Hydroxymitragynine is a potent alkaloid in kratom that plays a significant role in its analgesic and sedative effects. It holds potential for therapeutic use but also poses risks similar to those of opioids.
7-hydroxymitragynine Continued
Additional Information about 7-hydroxymitragynine
PubMed Articles
1. Mitragynine and 7-Hydroxymitragynine: The Two Main Active Compounds of the Emerging Natural Product Kratom
- Link: Mitragynine and 7-Hydroxymitragynine
- Summary: This review focuses on the pharmacodynamics, pharmacokinetics, and potential medicinal applications of mitragynine and 7-hydroxymitragynine, the two main active compounds in kratom.
2. Pharmacokinetics of Mitragynine and 7-Hydroxymitragynine in Rats
- Link: Pharmacokinetics in Rats
- Summary: This study investigates the pharmacokinetics of mitragynine and 7-hydroxymitragynine in rats, providing insights into their absorption, distribution, metabolism, and excretion.
3. 7-Hydroxymitragynine, an Active Alkaloid of the Plant Kratom (Mitragyna speciosa): State of the Art Review
- Link: State of the Art Review
- Summary: This review provides a comprehensive overview of 7-hydroxymitragynine, including its chemistry, pharmacology, and potential therapeutic uses
4. Involvement of 7-Hydroxymitragynine in the Antinociceptive Effects of Mitragynine in Mice
- Link: Antinociceptive Effects in Mice
- Summary: The study examines the role of 7-hydroxymitragynine in the pain-relieving effects of mitragynine, highlighting its significance in kratom's overall analgesic properties.
NIH Resources
1. National Center for Complementary and Integrative Health (NCCIH) - Kratom
- Link: NCCIH Kratom Overview
- Summary: This page provides an overview of kratom, including information on its active compounds such as 7-hydroxymitragynine, potential benefits, and associated risks.
2. National Institute on Drug Abuse (NIDA) - Kratom
- Link: NIDA Kratom Information
- Summary: This resource offers facts about kratom, including the pharmacological effects of its compounds like 7-hydroxymitragynine, and concerns related to its use.
3. PubChem - 7-Hydroxymitragynine
- Link: PubChem 7-Hydroxymitragynine
- Summary: PubChem provides detailed chemical information about 7-hydroxymitragynine, including its structure, properties, biological activities, safety, and toxicity data.
These resources should give you a comprehensive understanding of 7-hydroxymitragynine, its properties, effects, and current research.
